Promethazine HCl Oral Solution should be utilised with warning in patients with bone-marrow melancholy. Leukopenia and agranulocytosis are documented, generally when Promethazine (Promethazine HCl) continues to be Utilized in Affiliation with other identified marrow-harmful brokers.
The typical efficient dose of Promethazine for your active therapy of nausea and vomiting in small children or Grownups is 25 mg.
individuals that are allergic to promethazine, any of the elements in promethazine, or to other phenothiazines
Sufferers need to be encouraged to measure Promethazine HCl Oral Answer with an exact measuring unit. A household teaspoon will not be an exact measuring device and may lead to overdosage, particularly when a 50 percent a teaspoon is measured. A pharmacist can suggest an appropriate measuring unit and can provide Directions for measuring the proper dose. Promethazine HCl Oral Option may well lead to marked drowsiness or impair the psychological and/or Bodily skills essential to the effectiveness of probably harmful jobs, like driving a car or working machinery. Ambulatory individuals ought to be explained to in order to avoid engaging in this kind of activities right up until it is understood that they do not turn out to be drowsy or dizzy from promethazine therapy.
Promethazine HCl Oral Remedy and specific other medicines can interact with each other. Convey to your healthcare professional about each of the medicines you take which include prescription and non-prescription medicines, vitamins, and herbal nutritional supplements.
Prescription drug abuse will be the intentional non-therapeutic usage of a prescription drug, even at the time, for its worthwhile psychological or physiological outcomes.
No proof of tumorigenicity was noticed in male and female mice at codeine dietary doses approximately 400 mg/kg/day (about reminiscent of forty five instances the MRHD with a mg/m2 foundation).
Promethazine HCl Oral Option shouldn't be Employed in pediatric patients less than 2 yrs of age due to possible for lethal respiratory despair. Postmarketing situations of respiratory depression, which include fatalities, have already been described with use of promethazine in pediatric people lower than two years of age.
Labor or Supply Opioids cross the placenta and should produce respiratory depression and psycho-physiologic results in neonates. An opioid antagonist, for instance naloxone, need to be readily available for reversal of opioid-induced respiratory despair while in the neonate.
Promethazine HCl occurs for a white to faint yellow, practically odorless, crystalline powder which slowly but surely oxidizes and turns blue on prolonged publicity to air. It is actually freely soluble in drinking water and soluble in Liquor.
It can be crucial that Promethazine HCl Oral Option is measured using an precise measuring system (see PRECAUTIONS-Information and facts for Sufferers). A home teaspoon is not an precise measuring device and could lead on to overdosage, particularly when half a teaspoon will be to be measured.
Attention should be offered to your reestablishment of sufficient respiratory Trade through provision of a patent airway and institution of assisted or managed ventilation. Diazepam may very well be made use of to regulate convulsions. Acidosis and electrolyte losses needs to be corrected. Take note that any depressant outcomes of Promethazine HCl aren't reversed by naloxone. Stay away from analeptics which may lead to convulsions.
Promethazine HCl Oral Resolution ought click here to be applied in the course of pregnancy provided that the possible profit justifies the opportunity chance for the fetus.
Keep away from the usage of Promethazine HCl and Codeine Phosphate Oral Resolution in adolescents 12 to eighteen several years of age who have other threat elements which will enhance their sensitivity for the respiratory depressant consequences of codeine. Possibility factors include disorders affiliated with hypoventilation, like postoperative status, obstructive sleep apnea, being overweight, serious pulmonary disorder, neuromuscular disease, and concomitant utilization of other medications that lead to respiratory depression.